Dera Ghazi Khan is located at 30'03" N and 70'38" E. Dera Ghazi Khan is located in a strip between the river Indus and the Koh-e-Suleman range of mountains separating it from the Baluchistan Province. It is surrounded by Dera Ismail Khan on the North and Rajanpur on its South. Indus river flows on the East across which lies the districts of Muzafargarh and Layyah. Loralai and Dera Bugti districts of Baluchistan province lies on the west separated by the Koh-e-Suleman range of mountains. The district is spread over an area of 11,294 square kilometers comprising of following tehsils:
- Dera Ghazi Khan
- Kot Chutta
- Taunsa Sharif
- Koh-e-Suleman